abstract：:Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). F...

journal_title：Neurobiology of aging

authors： Samuraki M,Matsunari I,Chen WP,Shima K,Yanase D,Takeda N,Matsuda H,Yamada M

更新日期：2012-10-01 00:00:00

abstract：:This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and recover less cognitive and neurologic function than younger victims. Utilizing a rat traumatic brain injury model, sham surgery or a neocortical contusion was induced in 3 ...

journal_title：Neurobiology of aging

authors： Mehan ND,Strauss KI

更新日期：2012-09-01 00:00:00

abstract：:Here we employed human SHEP neuroblastoma cells either stably or inducibly expressing the amyloid precursor protein (APP) intracellular domain (AICD) to investigate its ability to modulate stress-induced cell death. Analysis of effector caspase activation revealed that AICD overexpression was specifically associated w...

journal_title：Neurobiology of aging

authors： Kögel D,Concannon CG,Müller T,König H,Bonner C,Poeschel S,Chang S,Egensperger R,Prehn JH

更新日期：2012-09-01 00:00:00

abstract：:Neuroinflammation is thought to play a pathogenic role in many neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). In this study we demonstrate that the expression of nitric oxide (NO) synthase-2 (NOS2), and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) with interferon-γ is higher i...

journal_title：Neurobiology of aging

authors： Valente T,Mancera P,Tusell JM,Serratosa J,Saura J

更新日期：2012-09-01 00:00:00

abstract：:Basal forebrain cholinergic neurons (BFCN), a system involved in learning and memory processes, are highly dependent on a continuous supply of biologically active nerve growth factor (NGF). Age-related cholinergic atrophy and cell loss in normal brains is apparently not complemented by reductions in the levels of NGF ...

journal_title：Neurobiology of aging

authors： Bruno MA,Cuello AC

更新日期：2012-09-01 00:00:00

abstract：:We recently reported that mutations in the valosin-containing protein (VCP) gene are a cause of 1%-2% of familial amyotrophic lateral sclerosis (ALS) cases, but their role in the pathogenesis of sporadic ALS is unclear. We undertook mutational screening of VCP in 701 sporadic ALS cases. Three pathogenic variants (p.Ar...

journal_title：Neurobiology of aging

authors： Abramzon Y,Johnson JO,Scholz SW,Taylor JP,Brunetti M,Calvo A,Mandrioli J,Benatar M,Mora G,Restagno G,Chiò A,Traynor BJ

更新日期：2012-09-01 00:00:00

abstract：:Iron is essential for triggering oligodendrocytes to myelinate, however, in gray matter (GM) iron increases with age and is associated with age-related degenerative brain diseases. Women have lower iron levels than men, both in the periphery and in the brain, particularly in white matter (WM), possibly due to iron los...

journal_title：Neurobiology of aging

authors： Tishler TA,Raven EP,Lu PH,Altshuler LL,Bartzokis G

更新日期：2012-09-01 00:00:00

abstract：:Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neuroto...

journal_title：Neurobiology of aging

authors： Galvan L,Lepejová N,Gaillard MC,Malgorn C,Guillermier M,Houitte D,Bonvento G,Petit F,Dufour N,Héry P,Gérard M,Elalouf JM,Déglon N,Brouillet E,de Chaldée M

更新日期：2012-08-01 00:00:00

abstract：:We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early-stage Alzheimer's disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy, and dementia progression. Individuals with early-stage AD (n = 37) and without dementia (...

journal_title：Neurobiology of aging

authors： Vidoni ED,Honea RA,Billinger SA,Swerdlow RH,Burns JM

更新日期：2012-08-01 00:00:00

abstract：:Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean a...

journal_title：Neurobiology of aging

authors： Flöel A,Suttorp W,Kohl O,Kürten J,Lohmann H,Breitenstein C,Knecht S

更新日期：2012-08-01 00:00:00

abstract：:Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX(3)CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx(3)cr1(gfp/gfp) (CX(3)CR1-deficient) o...

journal_title：Neurobiology of aging

authors： Chinnery HR,McLenachan S,Humphries T,Kezic JM,Chen X,Ruitenberg MJ,McMenamin PG

更新日期：2012-08-01 00:00:00

abstract：:HIV-1-infected brains are characterized by elevated depositions of amyloid beta (Aβ); however, the interactions between Aβ and HIV-1 are poorly understood. In the present study, we administered specific HIV-1 protein Tat into the cerebral vasculature of 50-52-week-old double transgenic (B6C3-Tg) mice that express a ch...

journal_title：Neurobiology of aging

authors： Chen L,Choi JJ,Choi YJ,Hennig B,Toborek M

更新日期：2012-08-01 00:00:00

abstract：:Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls. Compared wi...

journal_title：Neurobiology of aging

authors： Agosta F,Pievani M,Geroldi C,Copetti M,Frisoni GB,Filippi M

更新日期：2012-08-01 00:00:00

abstract：:The aim of this study was to estimate the number of new cells and neurons added to the dentate gyrus across the lifespan, and to compare the rate of age-associated decline in neurogenesis across species. Data from mice (Mus musculus), rats (Rattus norvegicus), lesser hedgehog tenrecs (Echinops telfairi), macaques (Mac...

journal_title：Neurobiology of aging

authors： Lazic SE

更新日期：2012-08-01 00:00:00

abstract：:Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. ...

journal_title：Neurobiology of aging

authors： Proitsi P,Lupton MK,Dudbridge F,Tsolaki M,Hamilton G,Daniilidou M,Pritchard M,Lord K,Martin BM,Johnson J,Craig D,Todd S,McGuinness B,Hollingworth P,Harold D,Kloszewska I,Soininen H,Mecocci P,Velas B,Gill M,Lawlor

更新日期：2012-08-01 00:00:00

abstract：:The retrogenesis hypothesis postulates that late-myelinated white matter fibers are most vulnerable to age- and disease-related degeneration, which in turn mediate cognitive decline. While recent evidence supports this hypothesis in the context of Alzheimer's disease, it has not been tested systematically in normal co...

journal_title：Neurobiology of aging

authors： Brickman AM,Meier IB,Korgaonkar MS,Provenzano FA,Grieve SM,Siedlecki KL,Wasserman BT,Williams LM,Zimmerman ME

更新日期：2012-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or "cognitive phenotype" is variable. The apolipoprotein E ε4 (APOE ε4) allele has been associated with an amnestic presentation, but does not appear to fully expla...

journal_title：Neurobiology of aging

authors： Vardy ER,Brown K,Stopford CL,Thompson JC,Richardson AM,Neary D,Kalsheker N,Morgan K,Mann DM,Snowden JS

更新日期：2012-07-01 00:00:00

abstract：:The aim of our study was to discover genomic variations related to variant Creutzfeldt-Jakob disease (vCJD) susceptibility. A genome-wide association analysis with most vCJD samples available in the world was performed. A series of 93 vCJD UK patients and 1504 UK controls were included in the discovery stage. Our best...

journal_title：Neurobiology of aging

authors： Sanchez-Juan P,Bishop MT,Aulchenko YS,Brandel JP,Rivadeneira F,Struchalin M,Lambert JC,Amouyel P,Combarros O,Sainz J,Carracedo A,Uitterlinden AG,Hofman A,Zerr I,Kretzschmar HA,Laplanche JL,Knight RS,Will RG,van Duijn

更新日期：2012-07-01 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK3B) and cyclin-dependent kinase 5 (CDK5) are the 2 major protein kinases involved in abnormal phosphorylation of tau. To determine their potential role in the pathogenesis of Parkinson's disease (PD) we analyzed 2 functional single nucleotide polymorphisms (SNPs) of GSK3B (rs334558 and ...

journal_title：Neurobiology of aging

authors： Das G,Misra AK,Das SK,Ray K,Ray J

更新日期：2012-07-01 00:00:00

abstract：:Reduced excitability, due to an increase in the slow afterhyperpolarization (and its underlying current sI(AHP)), occurs in CA1 pyramidal cells in aged cognitively-impaired, but not cognitively-unimpaired, rodents. We sought to determine whether similar age-related changes in the sI(AHP) occur in pyramidal cells in th...

journal_title：Neurobiology of aging

authors： Luebke JI,Amatrudo JM

更新日期：2012-06-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity, learning, and memory. Levels of BDNF and its main receptor TrkB (TrkB.TK) have been reported to be decreased while the levels of the truncated TrkB (TrkB.T1) are increased in Alzheimer's disease. We show here that incubation with ...

journal_title：Neurobiology of aging

authors： Kemppainen S,Rantamäki T,Jerónimo-Santos A,Lavasseur G,Autio H,Karpova N,Kärkkäinen E,Stavén S,Vicente Miranda H,Outeiro TF,Diógenes MJ,Laroche S,Davis S,Sebastião AM,Castrén E,Tanila H

更新日期：2012-06-01 00:00:00

abstract：:Chronic circadian disturbance, a condition of desynchronization between endogenous clock and environmental light-dark (LD) cycle, is known to cause adverse physiological changes including mortality. However, it is yet unclear whether these consequences result from disturbance of endogenous clock or condition of the LD...

journal_title：Neurobiology of aging

authors： Park N,Cheon S,Son GH,Cho S,Kim K

更新日期：2012-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. Several healthy lifestyle options and over-the-counter drugs that it has been suggested delay the onset of the disease are in an experimental phase, but it is unclear whether they will have any therap...

journal_title：Neurobiology of aging

authors： García-Mesa Y,Giménez-Llort L,López LC,Venegas C,Cristòfol R,Escames G,Acuña-Castroviejo D,Sanfeliu C

更新日期：2012-06-01 00:00:00

abstract：:Sleep benefits memory across a range of tasks for young adults. However, remarkably little is known of the role of sleep on memory for healthy older adults. We used 2 tasks, 1 assaying motor skill learning and the other assaying nonmotor/declarative learning, to examine off-line changes in performance in young (20-34 ...

journal_title：Neurobiology of aging

authors： Wilson JK,Baran B,Pace-Schott EF,Ivry RB,Spencer RM

更新日期：2012-05-01 00:00:00

abstract：:Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeost...

journal_title：Neurobiology of aging

authors： Viola AU,Chellappa SL,Archer SN,Pugin F,Götz T,Dijk DJ,Cajochen C

更新日期：2012-05-01 00:00:00

abstract：:Brain iron promotes neurodegeneration in Parkinson's disease (PD). While hemoglobin (Hb) is the most abundant source of peripheral iron in humans, its relationship with PD is uncertain. This report examines the association between Hb in late life and PD incidence. From 1991 to 1993, Hb was measured in 3507 men in the ...

journal_title：Neurobiology of aging

authors： Abbott RD,Ross GW,Tanner CM,Andersen JK,Masaki KH,Rodriguez BL,White LR,Petrovitch H

更新日期：2012-05-01 00:00:00

abstract：:Mimicking relevant behavioral features of the human pathology is one of the most important challenges for animal models of neurological disorders including Alzheimer disease (AD). Indeed, the most popular genetic AD mouse lines bearing mutations of the amyloid precursor protein (APP) and presenilin 1 genes (PS1), ofte...

journal_title：Neurobiology of aging

authors： Pietropaolo S,Delage P,Lebreton F,Crusio WE,Cho YH

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a genetically complex disorder for which the definite diagnosis is only accomplished postmortem. Mutations in 3 genes (APP, PSEN1, and PSEN2) are known to cause AD, but a large number of familial cases do not harbor mutations in these genes and several unidentified genes that contain diseas...

journal_title：Neurobiology of aging

authors： Guerreiro RJ,Lohmann E,Kinsella E,Brás JM,Luu N,Gurunlian N,Dursun B,Bilgic B,Santana I,Hanagasi H,Gurvit H,Gibbs JR,Oliveira C,Emre M,Singleton A

更新日期：2012-05-01 00:00:00

abstract：:Oxidative stress has been linked to noise- and drug-induced as well as age-related hearing loss. Antioxidants can attenuate the decline of cochlear structure and function after exposure to noise or drugs, but it is debated as to whether they can protect from age-related hearing loss. In a long-term longitudinal study,...

journal_title：Neurobiology of aging

authors： Sha SH,Kanicki A,Halsey K,Wearne KA,Schacht J

更新日期：2012-05-01 00:00:00

abstract：:Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic conditions of aging, including neurodegenerative and vascular disease. Because common neuronal mechanisms may mediate the adaptation to diverse cerebral insults, we hypothesized that susceptibility for age-related cognitive dec...

journal_title：Neurobiology of aging

authors： De Jager PL,Shulman JM,Chibnik LB,Keenan BT,Raj T,Wilson RS,Yu L,Leurgans SE,Tran D,Aubin C,Anderson CD,Biffi A,Corneveaux JJ,Huentelman MJ,Alzheimer's Disease Neuroimaging Initiative.,Rosand J,Daly MJ,Myers AJ,Reiman

更新日期：2012-05-01 00:00:00

abstract：:Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

journal_title：Neurobiology of aging

authors： Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptides in the brain, inducing neuronal cell death and microglial activation. Endoplasmic reticulum (ER) stress has been proposed to be a mediator of Aβ neurotoxicity. In this study, we test whether salubrinal, an ER stress inhibitor, can p...

journal_title：Neurobiology of aging

authors： Huang X,Chen Y,Zhang H,Ma Q,Zhang YW,Xu H

更新日期：2012-05-01 00:00:00

abstract：:Despite cognitive and physical declines, it has been suggested that older adults remain able to regulate their emotions effectively. However, whether this is true for all emotion regulation processes has not been established. We hypothesized that cognitive reappraisal, a form of emotion regulation requiring intact cog...

journal_title：Neurobiology of aging

authors： Opitz PC,Rauch LC,Terry DP,Urry HL

更新日期：2012-04-01 00:00:00

abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

journal_title：Neurobiology of aging

authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

更新日期：2012-04-01 00:00:00

abstract：:Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

journal_title：Neurobiology of aging

authors： Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

更新日期：2012-04-01 00:00:00

abstract：:The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaques in an object reco...

journal_title：Neurobiology of aging

authors： Francis BM,Kim J,Barakat ME,Fraenkl S,Yücel YH,Peng S,Michalski B,Fahnestock M,McLaurin J,Mount HT

更新日期：2012-03-01 00:00:00

abstract：:Mitochondrial dysfunction is likely a significant contributing factor to Alzheimer disease pathogenesis, and both amyloid peptide (Aβ) and pathological forms of tau may contribute to this impairment. Cleavage of tau at Asp421 occurs early in Alzheimer disease, and Asp421-cleaved tau likely negatively impacts neuronal ...

journal_title：Neurobiology of aging

authors： Quintanilla RA,Dolan PJ,Jin YN,Johnson GV

更新日期：2012-03-01 00:00:00

abstract：:Accumulating evidence indicates that white matter degeneration contributes to the neural disconnections that underlie Alzheimer's disease pathophysiology. Although this white matter degeneration is partly attributable to axonopathy associated with neuronal degeneration, amyloid β (Aβ) protein-mediated damage to oligod...

journal_title：Neurobiology of aging

authors： Horiuchi M,Maezawa I,Itoh A,Wakayama K,Jin LW,Itoh T,Decarli C

更新日期：2012-03-01 00:00:00

abstract：:It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day o...

journal_title：Neurobiology of aging

authors： Lövdén M,Schaefer S,Noack H,Bodammer NC,Kühn S,Heinze HJ,Düzel E,Bäckman L,Lindenberger U

更新日期：2012-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NM...

journal_title：Neurobiology of aging

authors： Vadakkadath Meethal S,Atwood CS

更新日期：2012-03-01 00:00:00